The frescoed image of the Madonna of the Lily was to be found in a roadside chapel in the area of Valiano, near the monastery, and was the object of great devotion because of its role in a miraculous event. So much so, in fact, that Pope Urban VIII, between 1642 and 1643, decided to have it moved to the Basilica of San Pietro in Perugia, in a chapel built expressly for that purpose. The work can be attributed to Giovanni di Pietro called lo Spagna, a painter from Spain who was strongly influenced by Perugino.